GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs6540731 | 1 | rs903121 | chr1:212405455 | NEK2 | chr1:211836115-211848967:- | -0.16 | -4.42 | 2.59E-5 | Intelligence (childhood) |
| THYM | cis | rs1875620 | 1 | rs905356 | chr9:91546375 | C9orf47 | chr9:91605778-91611055:+ | -0.26 | -4.7 | 8.7E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs2243480 | 1 | rs906134 | chr7:65444288 | CCT6P1 | chr7:65216092-65228661:+ | 0.65 | 5.32 | 6.97E-7 | Diabetic kidney disease |
| THYM | cis | rs911119 | 1 | rs911119 | chr20:23612737 | CST9 | chr20:23583049-23586610:- | 0.51 | 4.71 | 8.44E-6 | Chronic kidney disease |
| THYM | cis | rs4763879 | 1 | rs917911 | chr12:9905851 | CLECL1 | chr12:9868457-9885860:- | 0.46 | 4.97 | 3.0E-6 | Type 1 diabetes |
| THYM | cis | rs60843830 | 1 | rs9213 | chr2:218386 | SH3YL1 | chr2:218138-264810:- | -0.29 | -4.18 | 6.49E-5 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs1451375 | 1 | rs921450 | chr7:50623260 | FIGNL1 | chr7:50511834-50518088:- | 0.31 | 4.76 | 6.88E-6 | Malaria |
| THYM | cis | rs1451375 | 1 | rs921451 | chr7:50623285 | FIGNL1 | chr7:50511834-50518088:- | -0.3 | -4.64 | 1.09E-5 | Malaria |
| THYM | cis | rs9876781 | 1 | rs922075 | chr3:48489398 | TREX1 | chr3:48501186-48509043:+ | 0.28 | 4.29 | 4.29E-5 | Longevity |
| THYM | cis | rs2736345 | 1 | rs922483 | chr8:11351912 | BLK | chr8:11351521-11422107:+ | -0.4 | -4.94 | 3.3E-6 | Systemic lupus erythematosus |
| THYM | cis | rs10461617 | 1 | rs9283717 | chr5:56078659 | C5orf35 | chr5:56205103-56213010:+ | 0.74 | 8.92 | 3.44E-14 | Type 2 diabetes |
| THYM | cis | rs3820928 | 1 | rs9288617 | chr2:227762815 | RHBDD1 | chr2:227700773-227861591:+ | -0.32 | -4.73 | 7.77E-6 | Pulmonary function |
| THYM | cis | rs7615952 | 1 | rs9289275 | chr3:125648659 | LOC100125556 | chr3:125635444-125648865:+ | 0.7 | 5.51 | 3.01E-7 | Blood pressure (smoking interaction) |
| THYM | cis | rs10935120 | 1 | rs9289471 | chr3:134230811 | ANAPC13 | chr3:134196547-134204865:- | 0.57 | 7.9 | 4.94E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs9289471 | chr3:134230811 | CEP63 | chr3:134204575-134293852:+ | 0.41 | 6.16 | 1.71E-8 | Height |